In biology, most proteins exist in combinations of structural order and disorder, which has fostered a divide-and-conquer approach for their characterizations. However, emerging views point towards an important functional interplay between order and disorder, and from several examples it has now been shown that disorder may continue to exist in protein complexes and be of functional relevance. Only by studying intact proteins and context, we may understand function at its depth. From our studies on different protein systems, including membrane proteins and transcription factors where order and disorder co-exist and where disorder remain in complexes, I will highlight the role of context and stereochemistry for disorder-based interactions and focus on important functional outcomes of remaining disorder in protein complexes.