Magnetic resonance (MR) is one of the most important techniques for characterizing compositions, structure and dynamics of molecules. Over the past several years, quantum sensing with Nitrogen-Vacancy (NV) center has opened a new door for magnetic resonance spectroscopy of a single molecule. In my talk, I will mainly introduce several new results along the main line toward to in-situ magnetic resonance and the applications on both of methods and biology applications. (I) ESR spectroscopy of a single protein in poly-lysine and a single DNP duplex in aqueous solution. The work represents a step forward towards magnetic resonance investigation of biomolecules in their native environments at the single-molecule level. (II) Instead of bulk diamond, the nanodiamond with NVs has been used to record the electron spin resonance spectrum in-situ. We design a new control sequence to overcome the rotation issue of nanodiamond. (III) We realized magnetic detection of biomolecular interactions and immunomagnetic microscopy of tumor tissues with NV centers.
Reference
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