SABRE (Signal Amplification by Reversible Exchange) is a parahydrogen-based hyperpolarization method that has been developed to overcome the inherent insensitivity of NMR spectroscopy. It offers good potential for enhancing the detection of chemical compounds at low concentrations using NMR or MRI techniques.
Numerous studies have been conducted to explore the application of SABRE in biological systems, and the use of solid catalysts that can be separated from solutions expands the potential for applying SABRE to molecules with diverse biological activities.
Based on this, we aim to investigate the extent to which NMR signals from a molecule with biological activity can be amplified by SABRE with heterogeneous catalysts.