Poster Presentation 23rd International Society of Magnetic Resonance Conference 2023

Chemical composition of resin extract from indigenous Australian native plant (#245)

Andres Ruiz 1 , Gerry Turpin 2 , Matthew Perry 1 , Kate Miller 3 , Phurpa Wangchuk 1
  1. Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia
  2. Tropical Herbarium of Australia, James Cook University, Cairns, QLD, Australia
  3. College of Medicine and Dentistry , James Cook University , Cairns, QLD, Australia

An indigenous Australian plant found across regions from northern Queensland to New South Wales, has attracted considerable attention due to its medicinal properties, particularly its essential oils. However, there remains a dearth of research concerning the compounds derived from its resin. To bridge this knowledge gap, this study employed various techniques such as column chromatography, size exclusion, and multiple rounds of preparative high-performance liquid chromatography (HPLC) to isolate compounds from the resin. Structures of the compounds were elucidated using 1D NMR (1H and 13C NMR) and 2D NMR (COSY, HMBC, HSQC, NOESY) experiments. The analysis revealed the presence of flavonoids, including Sakuranetin and 7-methylaromadendrin, among the identified compounds. These particular flavonoids have been previously recognized for their potential anti-inflammatory properties, making them promising candidates for the development of new drugs.